Armillaria Mellea (Honey Fungus) Extract Powder 10:1, 20:1, 50:1 TLC, Polysaccharides 30% UV
【Other names】: Honey Fungus,Bootlace Fungus, Shoestring Fungus, Oak Fungus
【Botanical source】: Armillaria mellea (Vahl) P. Kumm.
【Part used】: Mycelium&Frutingbody
【Specification】: 10:1, 20:1, 50:1 TLC, Polysaccharides 30% UV
【Extraction solvents】: Water
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size
【Main ingredients】: The core components of Armillaria mellea include polysaccharides, adenosine, and ergosterol. Its characteristic active substances are coumarin compounds such as armillarisin A, which are crucial for exerting neuropharmacological effects. Additionally, it contains polypeptides, triterpenoids, and various trace elements. These components work synergistically to confer various biological activities such as sedation, calming the nerves, improving cerebral circulation, anticonvulsant activity, and neuroprotection.
【Storage conditions】：Store at room temperature in a sealed manner, away from light, and in a ventilated, cool, and dry environment.
【Shelf life】： 24 months from the production date

Armillaria Mellea (Honey Fungus) Extract Powder Production Flowchart
Armillaria Mellea frutingbody raw materials -Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Armillaria Mellea (Honey Fungus) Extract Powder

Extended Reading
Summary of Modern Research on Armillaria Mellea (Honey Fungus) Extract

1. Key Chemical Components:
   The primary bioactive components include polysaccharides(heteroglycans with glucose, galactose, mannose), armillaric acid(a unique sesquiterpenoid), and armillaridin (a coumarin derivative). It also contains ergosterol (and its peroxide), adenosine, various terpenoids, and phenolic compounds.
2. Documented Health Benefits & Mechanisms (In Vivo/In Vitro & Some Clinical):

• Neuroprotective & Sedative-Hypnotic Effects: Extracts demonstrate significant calming, anticonvulsant, and sleep-promoting activities in rodent models. The proposed mechanisms involve modulation of GABAergic and monoaminergic (serotonin, dopamine) neurotransmitter systems, contributing to its traditional use for neurasthenia and dizziness.
• Improvement of Cerebral & Peripheral Circulation: Clinical and animal studies indicate it can increase cerebral and coronary blood flow, reduce vascular resistance, and alleviate symptoms of vertigo and tinnitus. This is linked to adenosine content and vasorelaxant properties.
• Antioxidant & Anti-inflammatory: Polysaccharides and phenolics exhibit strong free radical scavenging activity and inhibit pro-inflammatory mediators (e.g., TNF-α, IL-6, NO), providing cellular protection.
• Antitumor & Immunomodulatory Potential: Polysaccharides enhance immune cell activity (macrophages, NK cells) and induce apoptosis in certain cancer cell lines (e.g., hepatoma, leukemia) in preclinical studies.
• Antimicrobial Activity: Shows inhibitory effects against various Gram-positive bacteria and fungi.

3. Interactions, Taboos, and Warnings:

• Drug Interactions:
  • CNS Depressants: May potentiate the effects of sedatives, hypnotics, or anticonvulsants (e.g., benzodiazepines, barbiturates).
  • Anticoagulants/Antiplatelets: Adenosine and other components may inhibit platelet aggregation, potentially increasing the risk of bleeding when combined with drugs like warfarin or aspirin.
  • Antihypertensives: Additive hypotensive effects are possible.
• Contraindications & Warnings:
  • Pregnancy & Lactation: Insufficient safety data; use is not recommended.
  • Surgery: Discontinue use at least 2 weeks prior to surgical procedures due to bleeding and CNS depression risks.
  • Autoimmune Diseases: Theoretical risk of immune stimulation; use with caution.
• General Caution: Raw or improperly prepared A. mellea can cause mild gastrointestinal distress in some individuals.

4. Applications:

• Pharmaceuticals & Nutraceuticals: Used in prepared extracts, tablets, and syrups (often in combination with Gastrodia elata) for treating vertigo, tinnitus, neurasthenia, and insomnia.
• Functional Foods: Incorporated into health tonics and beverages for neurohealth and immunity support.
• Cosmeceuticals: Explored in skincare for its antioxidant and anti-inflammatory properties.

References (Key Modern Research Articles)

1. Wang, X. H., Zhang, L., et al. (2017). “Extraction, purification and neuroprotective activity of polysaccharides from Armillaria mellea.” International Journal of Biological Macromolecules, 105(Pt 1), 477-483.
2. Lee, S. R., Lee, D., et al. (2019). “Armillaridin, a coumarin from Armillaria mellea, exerts neuroprotective effects by inhibiting microglial activation.” Journal of Natural Products, 82(11), 2923-2931.
3. Guan, C., Li, X., et al. (2021). “Armillaria mellea polysaccharides ameliorate cognitive impairment in D-galactose-induced aging mice via modulating gut microbiota and oxidative stress.” Food & Function, 12(24), 12880-12892.
4. Yin, X., You, Q., et al. (2010). “Antioxidant and antitumor activities of polysaccharides from Armillaria mellea.” Journal of Medicinal Plants Research, 4(24), 2697-2703.
5. Chen, Y., Xie, M., et al. (2012). “Chemical constituents and pharmacological activities of Armillaria mellea.” Journal of Traditional Chinese Medicine, 32(4), 659-663. (Review article).
6. Kim, H. W., Kim, B. K., et al. (2010). “Anti-inflammatory activity of edible mushroom Armillaria mellea.” Journal of the Korean Society for Applied Biological Chemistry, 53(6), 792-796.

 Disclaimer: This information consolidates current preclinical and limited clinical research. Pleurotus eryngii extract is a dietary supplement, not a medicine. Its effects can vary based on strain, cultivation, and extraction methods. Consultation with a healthcare provider is recommended before therapeutic use, especially for individuals with health conditions or those taking medications.