Sweet Wormwood(Artemisia Annua) Extract Powder 10:1, 20:1, 50:1 TLC
【Botanical source】: Artemisia annua L.
【Part used】: Root
【Specification】: 10:1, 20:1, 50:1 TLC
【Extraction solvents】: Water
【Appearance】: Brownish fine powder
【Particle size】: 95% pass 80 mesh size
【Main ingredients】: Sweet Wormwood(Artemisia Annua) mainly contains sesquiterpenoid lactones (such as artemisinin and dihydroartemisinin), flavonoids (such as quercetin), volatile oils, and coumarins. Artemisinin and its derivatives are the core components of its antimalarial properties, possessing unique peroxide groups that can efficiently kill malaria parasites. Other ingredients also contribute to a wide range of pharmacological activities such as anti-inflammatory, antiviral, and immune regulation.
【Storage conditions】：Store at room temperature in a sealed manner, away from light, and in a ventilated, cool, and dry environment.
【Shelf life】： 24 months from the production date

Sweet Wormwood(Artemisia Annua) Extract Powder Production Flowchart
Sweet Wormwood(Artemisia Annua) raw materials -Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Sweet Wormwood(Artemisia Annua) Extract Powder

Extended Reading
Modern Research on Sweet Wormwood (Artemisia annua) Extract

1. Chemical Components:
   The plant is renowned for its complex phytochemistry. The most critical compound is the sesquiterpene lactone artemisinin, which contains a unique endoperoxide bridge essential for its bioactivity. Other significant constituents include flavonoids(e.g., artemetin, chrysosplenetin), coumarins, volatile oils(camphor, pinene), and other terpenoids. Many flavonoids are studied for their role in enhancing artemisinin’s bioavailability and anti-parasitic activity.
2. Documented Health Benefits (Pharmacological Actions):

• Antimalarial: Artemisinin and its semi-synthetic derivatives (dihydroartemisinin, artemether, artesunate) are first-line treatments for uncomplicated Plasmodium falciparum malaria. They act rapidly by generating free radicals upon cleavage of the endoperoxide bridge in the presence of intraparasitic iron, causing oxidative damage to parasitic proteins.
• Antiviral: Extracts and artemisinin derivatives show broad-spectrum activity in vitro against viruses including SARS-CoV-2 (inhibiting replication), cytomegalovirus (CMV), hepatitis B and C viruses. The anti-inflammatory effects may also ameliorate viral infection complications.
• Anti-inflammatory & Immunomodulatory: Artemisinin compounds inhibit key signaling pathways (NF-κB, MAPK, STAT3) and reduce pro-inflammatory cytokines (TNF-α, IL-6), showing therapeutic potential in autoimmune diseases like lupus and arthritis, and in reducing inflammation-induced tissue damage.
• Anticancer: Artemisinin derivatives demonstrate selective toxicity toward cancer cells in vitro and in animal models, inducing apoptosis, ferroptosis (iron-dependent cell death), cell cycle arrest, and inhibiting angiogenesis. Clinical trials for adjunct cancer therapy are ongoing.
• Antibacterial & Antifungal: Exhibits activity against a range of bacteria, including drug-resistant strains like MRSA, and fungi such as Candida albicans.

III. Interactions, Taboos, and Warnings:

• Drug Interactions:
  • Anticoagulants/Antiplatelets: May increase risk of bleeding, especially with artesunate.
  • Strong Cytochrome P450 Inducers/Inhibitors: Artemisinin metabolism involves CYP enzymes (e.g., CYP2B6, CYP3A4); drugs affecting these enzymes may alter its efficacy or toxicity.
  • Other Antimalarials: Used in combination therapy to prevent resistance.
• Contraindications (Taboo): Pregnancy (first trimester) unless treating severe malaria, due to potential embryotoxicity in animal studies. Avoid in individuals with known hypersensitivity to Asteraceae/Compositae plants.
• Warnings/Side Effects: Artemisinin derivatives are generally safe but can cause dizziness, tinnitus, nausea, and transient neutropenia. Monotherapy or subtherapeutic doses are strongly discouraged to prevent development of artemisinin-resistant malaria parasites.

1. Applications:

• Pharmaceutical: The cornerstone of Artemisinin-based Combination Therapies (ACTs) for global malaria treatment. Artemisinin derivatives are also under investigation in clinical trials for cancer, viral infections, and autoimmune diseases.
• Herbal Supplements: Used in non-standardized capsules/tinctures for immune support, though efficacy for non-malarial indications is less established and quality varies.
• Traditional Medicine: Used in Traditional Chinese Medicine (TCM) for fever, inflammation, and malaria for centuries.
• Agricultural/Veterinary: Explored as a natural antiparasitic agent in livestock.

References

1. Tu, Y. (2011). The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nature Medicine, 17(10), 1217–1220.
2. World Health Organization (WHO). (2021). Guidelines for the treatment of malaria (4th ed.). Geneva.
3. Efferth, T., et al. (2021). Towards the use of artemisinin derivatives against SARS-CoV-2 infection. Phytomedicine, 91, 153713.
4. Li, Y. (2012). Qinghaosu (artemisinin): chemistry and pharmacology. Acta Pharmacologica Sinica, 33(9), 1141–1146.
5. Ho, W. E., Peh, H. Y., Chan, T. K., & Wong, W. S. (2014). Artemisinin: pharmacological actions beyond anti-malarial. Pharmacology & Therapeutics, 142(1), 126–139.
6. Krishna, S., et al. (2008). Artemisinins: mechanisms of action and potential for resistance. Drug Resistance Updates, 11(3), 81–91.
7. European Medicines Agency (EMA). (2006). Assessment report on Artemisia annua L., herba.

Note: This summary is for informational purposes. It may interact with medications and is contraindicated in certain conditions. Consult a healthcare professional before therapeutic use, particularly regarding its estrogenic activity.