Ashwagandha Extract Powder 10:1, 20:1, 50:1 TLC
【Botanical source】: Withania Somnifera
【Part used】: Roots of Withania Somnifera
【Specification】:  10:1 20:1 50:1TLC
【Appearance】: Brownish yellow fine powder
【Extraction solvents】: Water
【Particle size】: 95% pass 80 mesh size
【Main ingredients】: The main chemical component is Withanolides, which belongs to the steroid class and is divided into two structures: Type A/B. Pharmacological effects include: ① anti-inflammatory (inhibition of inflammatory factors); ② Antioxidant (neutralizing free radicals); ③ Immune regulation (enhancing NK cell activity); ④ Neuroprotection (regulating cortisol).

Ashwagandha Extract Extract Powder Production Flowchart
Ashwagandha raw materials -Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Ashwagandha Extract Powder

Extended Reading
Modern Pharmacological Effects of Ashwagandha Extract
Ashwagandha, a prominent adaptogen in Ayurvedic medicine, has garnered significant scientific interest due to its diverse bioactive compounds (withanolides, alkaloids, sitoindosides). Modern research has elucidated multiple pharmacological activities, primarily through preclinical studies and a growing number of clinical trials. Key findings include:

1. Neuroprotective & Cognitive Effects

• Mechanism: Modulates neurotransmitters (enhances GABAergic, possibly cholinergic activity), reduces oxidative stress in the brain, promotes neurite outgrowth, and may support synaptic plasticity.
• Evidence: Clinical trials suggest improvements in stress, anxiety, sleep quality, and cognitive function (memory, executive function) in adults. It is studied for potential adjunctive roles in conditions like mild cognitive impairment.

2. Adaptogenic & Stress-Response Modulation

• Mechanism: Regulates the hypothalamic-pituitary-adrenal (HPA) axis, significantly lowering cortisol levels. Enhances resilience to physical and psychological stressors.
• Evidence: Robust clinical data confirm its efficacy in reducing perceived stress scales and serum cortisol, improving overall well-being.

3. Anti-inflammatory & Immunomodulatory Effects

• Mechanism: Withanolides (e.g., withaferin A) inhibit key pro-inflammatory pathways (NF-κB, COX-2) and modulate immune cell activity.
• Evidence: Human studies show reduced inflammatory markers (CRP, IL-6). It may support immune function, though more clinical data is needed.

4. Endocrine & Metabolic Modulation

• Thyroid Function: May improve serum thyroid hormone levels (T3, T4) in subclinical hypothyroidism.
• Testosterone & Male Fertility: Several studies report increased testosterone, sperm concentration, and motility in men under stress or with infertility.
• Blood Sugar & Metabolism: Exhibits anti-diabetic properties by improving insulin sensitivity and reducing fasting blood glucose.

5. Musculoskeletal & Performance Benefits

• Evidence: Consistent findings from RCTs indicate it can increase muscle strength, power, and recovery in athletes and active adults. It also reduces fatigue and improves cardiorespiratory endurance.

6. Potential Anticancer Properties

• Mechanism (Preclinical): Withaferin A induces apoptosis, inhibits angiogenesis, and sensitizes cancer cells to radiation/chemotherapy in cell and animal models (e.g., breast, lung, colon cancers).
• Status: Promising but preliminary; no established clinical use in oncology beyond research settings.

7. Safety & Tolerability

• Generally well-tolerated in standardized root extracts at common doses (250-600 mg/day). Mild GI upset or drowsiness are possible.
• Contraindications/Interactions: Theoretical interaction with sedatives, thyroid hormones, and hypoglycemic drugs. Caution advised in pregnancy, autoimmune diseases, and before surgery.

Conclusion

Modern research supports ashwagandha’s traditional use as a broad-spectrum adaptogen. The strongest clinical evidence exists for its anti-stress, anxiety-reducing, cognitive-enhancing, and physical performance-improving effects. Its anti-inflammatory, endocrine-modulating, and neuroprotective properties provide a plausible mechanistic basis. However, more large-scale, long-term human trials are needed to solidify dosing, standardization (based on withanolide content), and specific therapeutic applications. It is considered a valuable complementary agent for stress-related disorders and overall resilience.