Atractylodes Macrocephala Extract Powder(Bai Zhu)10:1, 20:1, 50:1 TLC
【Botanical source】: Atractylodes macrocephala Koidz.
【Extraction source】: The dry rhizomes of Atractylodes macrocephala Koidz., a plant in the Asteraceae family. When the lower leaves wither and turn yellow in winter and the upper leaves become brittle, excavate them to remove sediment, dry or sun dry them, and then remove the fibrous roots.
【Functions in TCM】: Atractylodes macrocephala is a commonly used bulk Chinese medicinal herb, which has been passed down from generation to generation since the Tang and Song dynasties and has been used ever since. It has the effects of tonifying qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating, and preventing miscarriage. Indications: weak temper, fatigue and fatigue, insufficient appetite and bloating, loose and thin stools, cessation of water intake, poor urination, edema, phlegm and dizziness, dampness and soreness, qi deficiency and spontaneous sweating, and restless fetal movements.
【Specification】: 10:1, 20:1, 50:1 TLC
【Appearance】: Brownish yellow powder
【Particle size】: 95% pass 80 mesh size

Atractylodes Macrocephala Extract(Bai Zhu) Production Flowchart
Atractylodes Macrocephala – natural air drying–Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification of Atractylodes Macrocephala Extract(Bai Zhu)

Extended Reading
Pharmacological effects of Atractylodes Macrocephala (Bai Zhu)
1.Impact on the digestive system

The effect of Baizhu decoction on the in vitro intestinal motility of rabbits is related to the functional status of the intestinal tract. Under normal circumstances, Atractylodes macrocephala has an excitatory effect. When the intestinal tract is in an excited state under the action of acetylcholine, Atractylodes macrocephala exhibits an inhibitory effect; When the intestinal tract is inhibited by adrenaline, Atractylodes macrocephala also exhibits an excitatory effect, both of which can restore intestinal activity to near normal levels. Using the pigment glucan blue 2000 as a gastrointestinal marker, it was confirmed that the decoction of Atractylodes macrocephala has a significant effect on promoting gastric emptying and small intestine propulsion in mice. The administration of Atractylodes macrocephala decoction by gavage significantly enhances the movement of charcoal gel in the small intestine of mice. Atropine can significantly inhibit the excitatory effect of self surgery on the intestinal tract, and it is speculated that its excitatory effect on intestinal motility is mainly produced by stimulating M-cholinergic receptors. The decoction of Atractylodes macrocephala has an excitatory effect on gastrointestinal motility, while the volatile oil of Atractylodes macrocephala has an inhibitory effect. The volatile oil of Atractylodes macrocephala has a strong inhibitory effect on the spontaneous movement of the intestinal tract and an antagonistic effect on barium chloride, while the juniper cortex in the volatile oil has a stronger antagonistic effect on acetylcholine.

Anti ulcer
The acetone extract of Atractylodes macrocephala, administered orally, has a significant inhibitory effect on gastric mucosal damage caused by hydrochloric acid ethanol in rats. Administration via the duodenum has an inhibitory effect on the secretion of gastric juice in pyloric ligation rats, reducing the acidity of gastric juice and reducing the excretion of gastric acid and pepsin.

Protecting the liver
Oral administration of Atractylodes macrocephala decoction to mice can prevent and treat liver damage caused by carbon tetrachloride, alleviate liver glycogen reduction and hepatocyte degeneration and necrosis, promote hepatocyte growth, and reduce elevated ALT levels.

2. Enhance the body’s immune function
Atractylodes macrocephala can significantly enhance the ability of white blood cells to phagocytose Staphylococcus aureus. Atractylodes macrocephala polysaccharides can activate or synergistically promote the transformation of normal mouse lymphocytes with ConA and PHA within a certain concentration range, and significantly increase the level of IL-2 secretion. Hydrocortisone causes immunosuppression in mice, and polysaccharides from Atractylodes macrocephala have a restoring effect on the proliferation function of lymphocytes. They also increase the survival rate of spleen cells cultured in vitro in immunosuppressed mice, prolong the lifespan of lymphocytes, correct the disordered distribution of T cell subsets, and significantly increase the low level of IL-2.

3. Anti stress
Atractylodes macrocephala has the effects of anti fatigue and enhancing adrenal cortex function. Daily gavage of Atractylodes macrocephala decoction to mice for one month can increase weight, enhance physical strength, and prolong swimming time. Administration of Baizhu decoction by gavage can also enhance the physical strength and prolong swimming time of tumor bearing (cervical cancer U14) mice.

4. Enhance hematopoietic function
Atractylodes macrocephala has a promoting effect on red blood cell hematopoiesis in mice. Subcutaneous injection of Atractylodes macrocephala decoction into mice for 3 days significantly promoted the generation of erythropoietic progenitor cells.

5. Diuretic
Rats, rabbits, and rats who receive large doses of Atractylodes macrocephala decoction or liquid extract by gavage or intravenous injection have a significant and long-lasting diuretic effect, which can promote the excretion of electrolytes, especially sodium. Intravenous injection of Atractylodes macrocephala decoction into non anesthetized dogs resulted in a 9-fold increase in urine output, with the effect lasting for 5 hours; Gastric administration increases urine output by 2-3 times and lasts for 6-7 hours. Atractylodes macrocephala does not affect the antidiuretic effect of posterior pituitary hormone. The diuretic mechanism of Atractylodes macrocephala may be related to inhibiting electrolyte reabsorption and increasing the excretion of Na+, K+, and CI -.

6. Inhibiting uterine contractions
The efficacy of Atractylodes macrocephala in preventing miscarriage is related to its inhibitory effect on uterine contractions. The alcohol extract and petroleum ether extract of Atractylodes macrocephala showed significant inhibitory effects on spontaneous contractions of the ex vivo uterus of infertile mice, as well as on excitatory contractions of the uterus caused by oxytocin and motherwort, and the inhibitory effect increased with increasing drug concentration, showing a dose-response relationship. The alcohol extract of Atractylodes macrocephala can completely antagonize the tense contractions of oxytocin on the pregnant uterus of guinea pigs in vivo. The alcohol extract of Atractylodes macrocephala has a strong inhibitory effect on the isolated uterus, while the water extract has a weaker inhibitory effect.

7. Antioxidant and anti-aging effects
Atractylodes macrocephala has antioxidant effects. It can effectively inhibit lipid peroxidation, reduce the content of tissue lipid peroxides, avoid the damage of harmful substances to the structure and function of tissue cells, and resist the self oxidation hemolysis of mouse and human red blood cells. Atractylodes macrocephala can increase the SOD activity of red blood cells in mice over 12 months old, enhance the clearance of oxygen free radicals, reduce the damage of oxygen free radicals to the body, and inhibit the activity of monoamine oxidase B in the mouse brain. Oral administration of Atractylodes macrocephala decoction to aged mice for 4 weeks significantly increased the activity of GSH Px in whole blood and significantly reduced the content of MDA in red blood cells. Atractylodes macrocephala has the effect of delaying renal aging in elderly mice, and can significantly improve the renal structure of elderly mice.