Balloonflower Root(Platycodon Grandiflorum) Extract Powder 10:1, 20:1, 50:1 TLC
【Botanical source】: Platycodon grandiflorus (Jacq.) A.DC.
【Part used】: Root
【Specification】: 10:1, 20:1, 50:1 TLC
【Extraction solvents】: Water
【Appearance】: Brownish fine powder
【Particle size】: 95% pass 80 mesh size
【Main ingredients】: The main active ingredients of Platycodon grandiflorus are saponins, with Platycodon grandiflorus saponin D as the core component. It also contains polysaccharides, flavonoids, plant sterols, and polyenes. These ingredients endow it with significant anti-inflammatory, cough relieving, phlegm resolving, immune regulating, and hypoglycemic, lipid-lowering biological activities.
【Storage conditions】：Store at room temperature in a sealed manner, away from light, and in a ventilated, cool, and dry environment.
【Shelf life】： 24 months from the production date

Balloonflower Root(Platycodon Grandiflorum) Extract Powder Production Flowchart
Balloonflower Root(Platycodon Grandiflorum) raw materials -Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Balloonflower Root(Platycodon Grandiflorum) Extract Powder

Extended Reading
Modern Research on Balloonflower Root(Platycodon Grandiflorum) Extract Powder

Below is a detailed summary of modern research on Balloon Flower Root (Platycodon grandiflorum) Extract, commonly known as Jiegeng in Traditional Chinese Medicine.

1. Chemical Components

The primary bioactive constituents are triterpenoid saponins, collectively known as platycosides. Other significant compounds include:

• Saponins: Platycodin D is the most abundant and extensively studied marker compound, followed by platycodin A, C, and polygalacin D.
• Polysaccharides: Homogeneous and heterogenous polysaccharides with immunomodulatory activity.
• Flavonoids: Including platyconin and others.
• Phenols & Sterols: Such as sitosterol and stigmasterol.
• Inulin-type fructans: Acting as prebiotic dietary fibers.

2. Health Benefits & Mechanisms

The extract exhibits a wide range of pharmacological activities, primarily driven by platycodin D.

• Respiratory Health (Core Traditional Use): Potent expectorant and antitussive (cough-suppressing) effects. Saponins irritate the pharyngeal mucosa, reflexively increasing respiratory tract fluid secretion to dilute and expel phlegm. It also demonstrates anti-inflammatory effects in airway models.
• Anti-inflammatory & Immunomodulation: Modulates key inflammatory pathways (NF-κB, MAPK) and cytokine production. The polysaccharides can stimulate immune cell activity (e.g., macrophage phagocytosis), while saponins can exert anti-inflammatory and immunosuppressive effects depending on context.
• Anti-obesity & Hypolipidemic: Inhibits pancreatic lipase, reduces intestinal absorption of dietary fat, and promotes fatty acid oxidation. Studies show reduction in body weight, visceral fat, and serum triglycerides/cholesterol in animal models.
• Anticancer Potential: In vitro and in vivo studies show platycodin D induces apoptosis and cell cycle arrest in various cancer cell lines (e.g., lung, liver, colon, leukemia) through mitochondrial and caspase-dependent pathways.
• Hepatoprotective & Antioxidant: Protects liver cells from toxin- and alcohol-induced damage and demonstrates strong free radical scavenging activity.
• Neuroprotection & Cognitive Enhancement: Shows anti-neuroinflammatory effects and may improve memory and cognitive function in Alzheimer’s disease models by inhibiting acetylcholinesterase and reducing amyloid-beta toxicity.
• Antidiabetic: Improves insulin sensitivity and reduces blood glucose levels in diabetic models.

3. Drug & Supplement Interactions

• Anticoagulant/Antiplatelet Drugs (e.g., Warfarin, Aspirin): Potential Risk. Platycodin D may inhibit platelet aggregation. Concurrent use could theoretically increase bleeding risk. Close monitoring is advised.
• Antidiabetic Drugs: May have an additive blood glucose-lowering effect, potentially increasing hypoglycemia risk.
• Immunosuppressants: Due to its complex immunomodulatory effects, it may theoretically interfere with immunosuppressive therapy.
• Diuretics: The traditional use of “dispersing and discharging” may have a mild diuretic effect, potentially leading to additive effects.

4. Contraindications, Warnings & Side Effects

• Contraindications: Not recommended for individuals with active gastric ulcers or significant gastritis, as saponins can irritate the gastric mucosa. Contraindicated in cases of hemoptysis (coughing blood) in TCM theory.
• Pregnancy & Lactation: Insufficient safety data; traditional advisories recommend caution, especially during early pregnancy.
• Side Effects: At high doses, the most common side effects are gastrointestinal, including nausea, gastric discomfort, and diarrhea, due to the hemolytic and irritant properties of saponins.
• Allergy: Rare cases of allergic reaction are possible.

5. Applications

• Pharmaceuticals & Nutraceuticals: Core ingredient in cough syrups, expectorants, and throat lozenges. Also formulated in weight management, liver health, and immune support supplements.
• Functional Foods & Beverages: Used in herbal teas, soups, and health tonics, particularly in East Asia.
• Cosmeceuticals: Incorporated into skincare products for its anti-inflammatory and antioxidant properties.
• Animal Feed Additive: Studied for its growth-promoting and immunostimulant effects in livestock.

6. References (Key Modern Studies & Reviews)

1. Nyakudya, E., et al. (2020). “Platycodon grandiflorus (Jacq.) A.DC.: A Review of Phytochemistry, Pharmacology, and Toxicology.” Phytotherapy Research, 34(9), 1962-1978. (Comprehensive Review)
2. Lee, K. J., & Choi, C. Y. (2019). “Biological Activities and Potential Health Benefits of Platycodin D from Platycodon grandiflorus.” Molecules, 24(23), 4366.
3. Zhao, H. L., et al. (2018). “Platycodin D, a metabolite of Platycodon grandiflorum, inhibits highly metastatic MDA-MB-231 breast cancer growth and metastasis.” Frontiers in Pharmacology, 9, 1456.
4. Kim, J. Y., et al. (2021). “Anti-Obesity Effects of Platycodon grandiflorum Extract: A Review of In Vivo and In Vitro Studies.” Journal of Medicinal Food, 24(10), 1011-1021.
5. Han, L. K., et al. (2002). “Anti-obesity action of Salix matsudana leaves (Part 2). Isolation of anti-obesity effectors from polyphenol fractions of Salix matsudana.” Phytotherapy Research, 16(S1), 1-16. (Seminal paper on anti-obesity mechanism)
6. Choi, J. H., et al. (2017). “Platycodin D induces apoptosis and reduces metastatic potential in hepatocellular carcinoma cells.” Oncology Reports, 38(4), 2179-2186.
7. Zhai, Y., et al. (2018). “Structural characterization and immunomodulatory activity of a polysaccharide from Platycodon grandiflorum.” Carbohydrate Polymers, 193, 205-214.
8. Chinese Pharmacopoeia Commission. (2020). Pharmacopoeia of the People’s Republic of China. Vol. I. (Official Monograph for Standardization)

Note: This summary is for informational purposes. It may interact with medications and is contraindicated in certain conditions. Consult a healthcare professional before therapeutic use, particularly regarding its estrogenic activity.