Chaste Tree Fruit Extract Powder 10:1, 20:1, 50:1 TLC
【Botanical source】: Vitex agnus-castus
【Part used】: Fruits
【Specification】: 10:1, 20:1, 50:1 TLC
【Extraction solvents】: Water
【Appearance】: Brownish fine powder
【Particle size】: 95% pass 80 mesh size
【Main ingredients】: Chaste Tree Fruit mainly contains volatile oils (pinene, eucalyptol, etc.), flavonoids (quercetin, vitexin), terpenes, and alkaloids. It has pharmacological activities such as pain relief, anti-inflammatory, anti-tumor, blood pressure lowering, and microcirculation improvement. It is traditionally used for symptoms such as wind heat cold, headache, red eye swelling and pain, and neuropathic headache.
【Storage conditions】：Store at room temperature in a sealed manner, away from light, and in a ventilated, cool, and dry environment.
【Shelf life】： 24 months from the production date

Chaste Tree Fruit Extract Powder Production Flowchart
Rosehip raw materials -Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Chaste Tree Fruit Extract Powder

Extended Reading

Modern Research on Chaste Tree Fruit (Vitex agnus-castus) Extract

1. Chemical Components:
   The therapeutic activity is attributed to a complex mixture of diterpenes(e.g., rotundifuran, vitexilactone), flavonoids(casticin, orientin, isovitexin), iridoid glycosides (agnuside, aucubin), and essential oils (limonene, cineole, sabinene). The lipophilic components, particularly the diterpenes and flavonoids, are considered the primary bioactive compounds.
2. Documented Health Benefits (Pharmacological Actions):

• Dopaminergic & Hormonal Regulation: Its most validated mechanism is the dopamine agonist activity, leading to inhibition of prolactin release from the pituitary gland. This normalizes the estrogen-to-progesterone ratio, correcting luteal phase defects.
• Premenstrual Syndrome (PMS) & Premenstrual Dysphoric Disorder (PMDD): Numerous clinical trials and meta-analyses confirm its efficacy in reducing physical (mastalgia, bloating) and psychological (irritability, mood swings) symptoms of PMS/PMDD, comparable to conventional treatments.
• Menstrual Cycle Disorders & Fertility: Effective in managing irregular cycles, luteal insufficiency, and some cases of female infertility linked to hyperprolactinemia. Also used for symptoms of perimenopause.
• Anti-Inflammatory & Analgesic: Exhibits anti-inflammatory properties via inhibition of prostaglandin synthesis, contributing to pain relief in conditions like cyclic mastalgia.

III. Interactions, Taboos, and Warnings:

• Drug Interactions:
  • Dopamine Agonists/Antagonists: May have additive effects with drugs like bromocriptine or antagonistic effects with antipsychotics (e.g., haloperidol).
  • Hormonal Therapies: May interfere with the action of oral contraceptives, hormone replacement therapy (HRT), or fertility medications.
  • Dopaminergic Medications for Parkinson’s: Potential for interaction.
• Contraindications (Taboo): Pregnancy and breastfeeding (due to hormonal influence). Not recommended for individuals with hormone-sensitive conditions (e.g., breast, uterine, or ovarian cancer; endometriosis). Avoid use in children and in patients taking antipsychotics.
• Warnings/Side Effects: Generally well-tolerated. Mild and transient side effects may include gastrointestinal upset, headache, dizziness, acne, and pruritus. Can cause cycle irregularities initially.

1. Applications:

• Pharmaceutical/Nutraceutical: Standardized extracts (often to casticin or agnuside) are widely used in capsules, tablets, and tinctures for managing PMS, PMDD, cyclic mastalgia, and irregular menstrual cycles.
• Women’s Health Integrative Therapy: A first-line herbal therapy in complementary and alternative medicine for menstrual complaints and subfertility.
• Veterinary Medicine: Occasionally used in small animal practice for hormonal imbalances.

References

1. Dante, G., & Facchinetti, F. (2011). Herbal treatments for alleviating premenstrual symptoms: a systematic review. Journal of Psychosomatic Obstetrics & Gynecology, *32*(1), 42-51.
2. van Die, M. D., Burger, H. G., Teede, H. J., & Bone, K. M. (2013). Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Medica, *79*(07), 562-575.
3. Wuttke, W., Jarry, H., Christoffel, V., Spengler, B., & Seidlová-Wuttke, D. (2003). Chaste tree (Vitex agnus-castus)—Pharmacology and clinical indications. Phytomedicine, *10*(4), 348-357.
4. Cerqueira, R. O., Frey, B. N., Leclerc, E., & Brietzke, E. (2017). Vitex agnus-castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Archives of Women’s Mental Health, *20*(6), 713–719.
5. Hajdú, Z., Hohmann, J., Forgo, P., et al. (2007). Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. Phytotherapy Research, *21*(4), 391-394.
6. European Medicines Agency (EMA). (2010). Assessment report on Vitex agnus-castus L., fructus.

Note: This summary is for informational purposes. It may interact with medications and is contraindicated in certain conditions. Consult a healthcare professional before therapeutic use, particularly regarding its estrogenic activity.