Coptidis (Huang Lian) Extract Powder 10:1, 20:1, 50:1 TLC
【Other names】: Huang Lian, Rhizoma Coptidis, Rhizome of Chinese goldthread, Chuan Huang Lian, Chuan Lian
【Botanical source】: Coptis chinensis Franch, Coptis deltoidea C.Y.Cheng et Hsia or Coptis teeta Wall.
【Part used】: Dry rhizomes of Coptis chinensis Franch, Coptis deltoidea C.Y. Cheng et Hsiao, or Coptis teeta Wall in the Ranunculaceae family. Excavate in autumn, remove fibrous roots and sediment, dry, and knock off residual fibrous roots.
【Specification】: 10:1, 20:1, 50:1 TLC
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size

Coptidis (Huang Lian) Extract Powder Production Flowchart
Coptidis (Huang Lian) raw materials – natural air drying–Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Coptidis (Huang Lian) Extract Powder

Extended Reading
Coptidis (Huang Lian) Function and Efficacy Recorded in TCM
Huanglian is a highly distinctive and important medicine in traditional Chinese medicine, known as the “traditional Chinese medicine antibiotic”. Its nature is bitter and cold, and it belongs to the meridians of the heart, stomach, liver, gallbladder, and large intestine. Its function is very strong and specific, with the core being to “clear and eliminate fire evil, dry and transform dampness and turbidity”.

The following are the detailed functions of Huanglian in traditional Chinese medicine:

1.Clearing heat and drying dampness – essential medicine for treating damp heat diseases
This is the most core and commonly used efficacy of Huanglian. Especially adept at clearing the dampness and heat of the middle and lower energizer (spleen and stomach, intestines).

Application:
Damp heat in the gastrointestinal tract, diarrhea and abdominal pain: these are the “ace” indications of Huanglian. For diseases such as bacterial dysentery and acute gastroenteritis that present as urgency, pus and blood in the stool, and burning sensation in the anus, the therapeutic effect is remarkable. Often used in combination with wood fragrance, Scutellaria baicalensis, etc., such as Xianglian Pill and Gegen Qinlian Decoction.

Damp heat obstruction, vomiting in the epigastric region: used for dampness and heat to trap the spleen and stomach, causing chest and epigastric congestion, nausea and vomiting, and yellow and greasy tongue coating. Often used interchangeably with Huangqin, dried ginger, and Banxia, such as Banxia Xiexin Tang.

2.Diarrhea and Detoxification – The power of clearing excess heat and detoxifying is extremely strong
Huanglian can clear the prevalent fire pathogens and heat toxins in the human body, especially adept at clearing the solid fire in the heart meridian and stomach meridian.

Application:
Heart fire hyperactivity: manifested as high fever, restlessness, insomnia, frequent dreams, mouth and tongue sores, and even delirium. Often combined with Scutellaria baicalensis, Gardenia jasminoides, etc., such as Huanglian Jiedu Tang.

Excessive stomach fire: manifested as gum swelling and pain, oral ulceration, hunger relief (eating too much but easily getting hungry), and excessive thirst and drinking. Often used interchangeably with Shengma and Shengdi, such as Qingwei San.

Swelling and sores, ear and eye swelling and pain: Huanglian can be used orally or topically to treat skin suppurative infections, acute conjunctivitis, otitis media, etc. caused by excessive fire toxicity. The famous prescription Huanglian Jiedu Tang is representative.

3.Clearing the mind and eliminating troubles
This is a concrete manifestation of the efficacy of “purging fire and detoxifying” in the Heart Meridian.

Application: It is mainly used in the process of fever, where heat pathogens invade the pericardium, causing high fever, restlessness, and confusion. It is an important drug for treating heat disturbance and mental state.

Modern Pharmacological Effects of Coptidis (Huang Lian)
The modern pharmacological effects of Huanglian have been extensively studied, with its core active ingredient being berberine (also known as berberine), in addition to berberine, palmatine alkaloids, and root alkaloids. These studies perfectly confirm their traditional efficacy from a scientific perspective. The following are the main modern pharmacological effects of Huanglian:

1. Antipathogenic Microbial Action – “Traditional Chinese Medicine Antibiotics”
This is the most direct proof of its ability to clear heat, dry dampness, eliminate fire, and detoxify.

Wide antibacterial spectrum: Berberine has significant inhibitory effects on various Gram positive bacteria (such as Staphylococcus aureus, Streptococcus pyogenes) and Gram negative bacteria (such as Shigella, Salmonella typhi, Escherichia coli).

Antiviral: It has a certain inhibitory effect on influenza virus, hepatitis virus, herpes virus, etc.

Antifungal and antiparasitic: It has inhibitory effects on dermatophytes, Candida albicans, amoebas, trichomonas, and other fungi.

Application association: This scientifically explains why Huanglian is an essential medicine for treating damp heat and fire toxin syndromes such as intestinal infections (diarrhea, dysentery), skin infections, respiratory infections, etc.

2. Anti inflammatory, antipyretic, and immune regulation
Anti inflammatory: Berberine can inhibit the production and release of various inflammatory mediators, such as prostaglandins, leukotrienes, tumor necrosis factor alpha, etc., thereby reducing the inflammatory response.

Antipyretic: It has a clear antipyretic effect on experimental febrile animals.

Immune regulation: Low doses can enhance immune function, while high doses may suppress immunity. This bidirectional regulation is related to its complex role in treating autoimmune diseases and combating infections.

3.Effects on the cardiovascular system
Antiarrhythmic: Berberine can prolong the action potential duration and effective refractory period of myocardial cells, and has good therapeutic effects on ventricular and supraventricular arrhythmias caused by various reasons. It is a broad-spectrum antiarrhythmic drug.

Lowering blood pressure: By inhibiting acetylcholinesterase and enhancing acetylcholine activity, blood vessels dilate, thereby lowering blood pressure.

Protecting the myocardium and improving heart failure: can enhance myocardial contractility, reduce pre – and post cardiac load, and have an improving effect on heart failure.

4. Lowering blood sugar and regulating blood lipids
This is a remarkable achievement of Huanglian in modern research, expanding its traditional applications.

Lowering blood sugar:
Mechanism: Berberine not only promotes insulin secretion, but more importantly, it can improve insulin resistance and increase peripheral tissue uptake and utilization of glucose by activating the AMPK signaling pathway.

Status: At present, berberine has become a commonly used adjuvant for clinical treatment of type 2 diabetes, especially for patients with insulin resistance.

Regulation of blood fat: it can effectively reduce the levels of serum total cholesterol, triglycerides and low-density lipoprotein cholesterol, which is of great significance in the prevention and treatment of atherosclerosis.

5. Effects on the digestive system
Anti ulcer: It has a preventive and therapeutic effect on experimental gastric ulcers by inhibiting gastric acid secretion and protecting the gastric mucosa.

Antidiarrheal: In addition to its antibacterial effect, berberine itself can also reduce intestinal secretion and inhibit intestinal smooth muscle peristalsis, thereby exerting an antidiarrheal effect.

6.Antitumor effect
A large number of studies have shown that berberine can inhibit the proliferation, induce apoptosis, inhibit invasion and metastasis of a variety of tumor cells (such as lung cancer, liver cancer, gastric cancer, colorectal cancer, breast cancer, etc.).

Mechanism: It involves multiple signaling pathways, such as inducing cell cycle arrest, regulating apoptosis related proteins, and inhibiting tumor angiogenesis.

Attention: This is still at the forefront of research and has not yet become a mature clinical anti-cancer drug, but it shows great potential.

7.Neuroprotective effect
Research has found that berberine has protective potential against neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and cerebral ischemia. Its mechanism is related to antioxidant, anti-inflammatory, acetylcholinesterase inhibition, and reduction of β – amyloid protein deposition.