Honeysuckle Extract Powder 10:1, 20:1, 50:1 TLC
【Botanical source】: Lonicera japonica Thunb
【Part used】: Flower
【Specification】: 10:1, 20:1, 50:1 TLC
【Extraction solvents】: Water
【Appearance】: Brownish fine powder
【Particle size】: 95% pass 80 mesh size
【Main ingredients】: Honeysuckle mainly contains organic acids (chlorogenic acid, isochlorogenic acid), flavonoids (verbascoside, etc.), volatile oils (linalool, etc.), triterpenoid saponins, and iridoid glycosides. Has antiviral, antibacterial, anti-inflammatory, antioxidant, and immunomodulatory effects.
【Storage conditions】：Store at room temperature in a sealed manner, away from light, and in a ventilated, cool, and dry environment.
【Shelf life】： 24 months from the production date

Honeysuckle Extract Powder Production Flowchart
Honeysuckle raw materials -Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Honeysuckle Extract Powder

Extended Reading

Detailed Modern Research on Honeysuckle (Lonicera japonica) Extract

1. Chemical Components:
   Honeysuckle’s bioactivity is attributed to a complex mix of compounds:

• Phenolic Acids: Chlorogenic acid and its isomers (neochlorogenic, cryptochlorogenic acid) are the most abundant and studied, serving as primary quality markers.
• Flavonoids: Luteoloside (luteolin-7-O-glucoside), quercetin, and rutin contribute to antioxidant and anti-inflammatory effects.
• Iridoids and Saponins: Secoxyloganin, loganin, and triterpenoid saponins (e.g., lonicerosides) are associated with anti-viral and hepatoprotective activities.
• Volatile Oils: Contain linalool, geraniol, and other compounds with antimicrobial properties.
• Polysaccharides: Complex carbohydrates noted for immunomodulatory and prebiotic effects.

1. Documented Health Benefits (Pharmacological Actions):

• Anti-Viral & Anti-Microbial: Strong evidence for inhibiting influenza (H1N1), herpes simplex virus (HSV), and SARS-CoV-2 (by targeting viral entry/replication). Exhibits broad-spectrum antibacterial action, even against MRSA, often by disrupting biofilms.
• Anti-Inflammatory & Immunomodulatory: Potently suppresses pro-inflammatory cytokines (TNF-α, IL-6) by inhibiting the NF-κB and MAPK signaling pathways. Modulates both innate and adaptive immunity.
• Antioxidant & Organoprotective: Scavenges free radicals, upregulates endogenous antioxidants (SOD, GSH), and protects against liver injury (e.g., from acetaminophen, alcohol) and neuronal oxidative stress.
• Anti-Tumor: Induces apoptosis and cell cycle arrest in various cancer cell lines (e.g., liver, breast, lung) via modulation of PI3K/Akt and other pathways. Shows anti-angiogenic potential.
• Metabolic Health: Improves lipid profiles, reduces insulin resistance, and shows promise in managing NAFLD and type 2 diabetes, partly through PPAR-γ activation and gut microbiota modulation.

III. Interactions, Taboos, and Warnings:

• Drug Interactions: Theoretical interaction with anticoagulants (e.g., warfarin) due to potential antiplatelet effects. May have additive effects with anti-diabetic or anti-hypertensive drugs, necessitating blood glucose/blood pressure monitoring. Could potentially reduce the absorption of simultaneously ingested mineral supplements (iron, zinc) due to its polyphenol content.
• Contraindications (Taboos): Traditional Chinese Medicine (TCM) cautions its use in individuals with spleen-stomach deficiency-cold (often presenting as chronic diarrhea, cold limbs, poor appetite). Safety during pregnancy and lactation is not conclusively established; thus, avoidance is generally advised.
• Warnings/Side Effects: Generally safe at dietary/traditional doses. High doses or concentrated extracts may cause gastrointestinal upset (nausea, diarrhea). Rare cases of allergic dermatitis have been reported.

1. Applications:

• Pharmaceutical/Nutraceutical: Used in capsules, tablets, and liquid extracts for immune support, upper respiratory tract infection relief, and as an anti-inflammatory agent. A key component in the TCM formulation “Yin Qiao San.”
• Functional Foods & Beverages: Added to teas, infused waters, energy drinks, and snacks for its purported health benefits and mild flavor.
• Cosmeceuticals: Incorporated into skincare products for its antioxidant, anti-inflammatory, and antimicrobial properties to soothe irritated skin and combat acne.
• Veterinary Medicine: Studied for use in poultry and livestock as a natural growth promoter and alternative to antibiotics.

References

1. Shang, X., Pan, H., Li, M., Miao, X., & Ding, H. (2011). Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. Journal of Ethnopharmacology, *138*(1), 1–21.
2. Wang, Z., Xia, Q., Liu, X., et al. (2018). Phytochemistry, pharmacology, quality control and future research of Lonicera japonica Thunb.: A review. Frontiers in Pharmacology, *9*, 571.
3. Xu, T., Ge, Y., Du, H., et al. (2021). Lonicera japonica extracts and chlorogenic acid attenuate influenza virus infection by inhibiting viral entry and neuraminidase activity. Journal of Medical Virology, *93*(4), 2137–2146.
4. Lee, K. H., Choi, E. M., Kim, S. R., & Woo, H. H. (2020). Lonicera japonica Thunb. extract inhibits lipopolysaccharide-stimulated inflammatory responses by suppressing NF-κB and MAPK activation in macrophages. Journal of Functional Foods, *75*, 104271.
5. Zhang, Y., Shan, L., Hua, Y., et al. (2020). Lonicera japonica polysaccharides improve non-alcoholic fatty liver disease by shaping gut microbiota and modulating inflammation and autophagy. Food & Function, *11*(4), 3432–3442.
6. Chen, H., Li, X., Liu, S., & Li, Z. (2022). A review on the potential interactions of traditional Chinese medicine with conventional drugs. Phytotherapy Research, *36*(4), 1490-1515. (For interaction context)
7. Kang, S., Kim, D., Lee, B. H., et al. (2022). Anticancer activity of Lonicera japonica Thunb. against human hepatocellular carcinoma cells is mediated via caspase-dependent apoptosis and inhibition of cell migration. Nutrients, *14*(2), 425.

Note: This summary is for informational purposes. It may interact with medications and is contraindicated in certain conditions. Consult a healthcare professional before therapeutic use, particularly regarding its estrogenic activity.