Irpex Lateus (White Tine Bacteria Mushroom) Extract Powder 10:1, 20:1, 50:1 TLC, Polysaccharides 30% UV
【Botanical source】: Irpex lacteus (Fr.) Fr.）
【Part used】: Mycelium&Frutingbody
【Specification】: 10:1, 20:1, 50:1 TLC, Polysaccharides 30% UV
【Extraction solvents】: Water
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size
【Main ingredients】: The main active components of Irpex lacteus are polysaccharides (such as β-glucan), triterpenoids (such as fibuligerone), and polyphenols. Its distinctive feature lies in its rich content of lanostane-type triterpenoids, which exhibit clear anti-inflammatory and cytoprotective activities. Additionally, it contains sterols, melanin, and other compounds. These components collectively confer its pharmacological effects, including antioxidant, immunomodulatory, and hepatoprotective activities.
【Storage conditions】：Store at room temperature in a sealed manner, away from light, and in a ventilated, cool, and dry environment.
【Shelf life】： 24 months from the production date

Irpex Lateus (White Tine Bacteria Mushroom) Extract Powder Production Flowchart
Armillaria Mellea frutingbody raw materials -Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Irpex Lateus (White Tine Bacteria Mushroom) Extract Powder

Extended Reading
Summary of Modern Research on Irpex lacteus Extract

1. Key Chemical Components:
   The fungus is a prolific producer of ligninolytic enzymes(laccase, manganese peroxidase, versatile peroxidase), crucial for its biotechnological applications. Its pharmacologically active metabolites include diverse sesquiterpenoids(especially fomannosin derivatives), polyketides, triterpenoids, and polysaccharides (β-glucans). Specific compounds like irpexlacte A–G (sesquiterpenes) and lactones have been isolated and characterized.
2. Documented Health Benefits & Mechanisms (Predominantly In Vitro & Preclinical):

• Anticancer & Cytotoxic Activity: Extracts and isolated sesquiterpenoids (e.g., fomannosins) show potent cytotoxic effects against various human cancer cell lines (e.g., breast MCF-7, lung A549, leukemia HL-60) by inducing apoptosis and cell cycle arrest.
• Anti-inflammatory & Immunomodulatory: Extracts significantly inhibit the production of nitric oxide (NO) and pro-inflammatory cytokines (TNF-α, IL-6) in LPS-stimulated macrophages by suppressing NF-κB and MAPK signaling pathways. Polysaccharides exhibit immune-enhancing effects.
• Antimicrobial & Antifungal: Demonstrates broad-spectrum activity against Gram-positive bacteria (e.g., Staphylococcus aureus), plant pathogenic fungi, and human dermatophytes, linked to its secondary metabolites.
• Neuroprotective Potential: Emerging research indicates certain extracts may protect neuronal cells against oxidative stress and glutamate-induced excitotoxicity, suggesting potential for neurodegenerative disease research.
• Hepatoprotective Activity: Shown to protect liver cells from chemical-induced damage (e.g., CCl₄) in animal models, attributed to its antioxidant and anti-inflammatory properties.

3. Interactions, Taboos, and Warnings:

• Drug Interactions: Potential pharmacodynamic interactions due to strong enzymatic activity and bioactive metabolites.
  • May interfere with drugs metabolized by cytochrome P450 enzymes.
  • Immunomodulatory effects warrant caution with immunosuppressants.
  • Theoretical additive risk of bleeding when combined with anticoagulants.
• Contraindications & Warnings:
  • Pregnancy & Lactation: No safety data; use is contraindicated.
  • Pre-/Post-Surgery: Discontinue use due to potential immune and bleeding effects.
  • Allergies: General caution for individuals with mushroom allergies.
  • Underlying Conditions: Patients with autoimmune disorders or bleeding diatheses should avoid use.
• General Safety: Comprehensive human toxicity data is lacking. Most research is in early, preclinical stages.

4. Applications:

• Bioremediation & Industry: Primarily used for its enzymes in biopulping, bioleaching, dye decolorization, and degrading environmental pollutants (pesticides, endocrine disruptors).
• Pharmaceutical Development: Investigated as a source of novel anticancer, anti-inflammatory, and antimicrobial lead compounds.
• Agriculture: Explored as a biocontrol agent against plant pathogens.
• Nutraceuticals: Limited but growing interest in its polysaccharide extracts for immune support.

References (Key Modern Research Articles)

1. Schwantes, V., et al. (2017). “Anticancer and anti-inflammatory sesquiterpenoids from the fungus Irpex lacteus.” Journal of Natural Products, 80(3), 771-775.
2. Lee, I. K., et al. (2016). “Fomannosins and related compounds from the wood-decaying fungus Irpex lacteus and their cytotoxic activity.” Phytochemistry Letters, 16, 236-240.
3. Zhao, C., et al. (2015). “Anti-inflammatory sesquiterpenoids from the fungus Irpex lacteus.” Bioorganic & Medicinal Chemistry Letters, 25(19), 4329-4331.
4. Novotný, Č., et al. (2004). “Ligninolytic fungi in bioremediation: extracellular enzyme production and degradation rate.” Soil Biology and Biochemistry, 36(10), 1545-1551. (Focus on enzymatic applications).
5. Wang, G., et al. (2020). “Polysaccharides from Irpex lacteus mycelia ameliorate cyclophosphamide-induced immunosuppression via regulating gut microbiota.” International Journal of Biological Macromolecules, 164, 3682-3691.
6. Kim, J. H., et al. (2013). “Neuroprotective effects of Irpex lacteus against glutamate-induced oxidative stress in HT22 hippocampal neuronal cells.” Journal of Microbiology and Biotechnology, 23(7), 964-970.

Disclaimer: This information consolidates current preclinical and limited clinical research. Pleurotus eryngii extract is a dietary supplement, not a medicine. Its effects can vary based on strain, cultivation, and extraction methods. Consultation with a healthcare provider is recommended before therapeutic use, especially for individuals with health conditions or those taking medications.