Semen Coicis (Yi Yi Ren) Extract Powder 10:1, 20:1, 50:1 TLC
【Other names】: Semen Coicis, Yi Mi, Yi Yi Ren, Yi Ren, Coix Seed, Job’s tears
【Botanical source】: Coix lacryma-jobi L.var.mayuen (Roman.) Stapf
【Part used】: Dry and mature seeds of Coix lacryma jobi L. var. mayuen (Roman.) Stapf, a grass family plant. When the autumn fruits are ripe, the plants are harvested, dried, the fruits are harvested, and then dried to remove the outer shell, yellow brown seed coat, and impurities, and the seeds are collected.
【Specification】: 10:1, 20:1, 50:1 TLC
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size

Semen Coicis (Yi Yi Ren) Extract Powder Production Flowchart
Semen Coicis (Yi Yi Ren) raw materials – natural air drying–Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing
Specification Sheet of Semen Coicis (Yi Yi Ren) Extract Powder

Extended Reading
Semen Coicis (Yi Yi Ren) Function and Efficacy Recorded in TCM
Coix seed is a very important and commonly used medicinal herb in traditional Chinese medicine, with a wide range of effects and a balanced medicinal property. The following is a detailed explanation of the main functions, applications, and precautions of Coix seed in traditional Chinese medicine theory.

The core functions of Coix seed can be summarized as: promoting diuresis and dampness, strengthening the spleen and stopping diarrhea, removing rheumatism, expelling pus, detoxifying and dispersing nodules. Its medicinal properties are slightly cold, with a sweet and mild taste, and it returns to the spleen, stomach, and lung meridians.

1. Promote diuresis and dampness, strengthen the spleen and stop diarrhea
This is the most well-known efficacy of Coix seed. Mechanism of action: Coix seed has a mild taste and can penetrate dampness. It has a cold nature and can clear heat, especially good at clearing “dampness and heat” in the body. At the same time, it enters the Spleen Meridian, which can strengthen the spleen and promote digestion, reducing the production of water and dampness from the root.

Main applications:
Edema and urinary discomfort: For edema and athlete’s foot swelling caused by dampness and heat, it is often combined with Poria cocos, Poria cocos, and other ingredients.

Diarrhea caused by spleen deficiency and excessive dampness: manifested as loose stools, increased frequency, feeling unable to clean thoroughly (urgent and severe), and thick and greasy tongue coating. Often used together with spleen strengthening medicines such as Atractylodes macrocephala, Poria cocos, and Yam, such as Shen Ling Bai Zhu San.

Damp heat syndrome: such as burning and astringent pain in urine, often combined with Plantago asiatica, talc, etc.

2. Clear heat and discharge pus
Coix seed can clear the heat in the lungs and intestines, expel pus and eliminate carbuncles.

Main applications:
Lung abscess: equivalent to modern lung abscess, bronchiectasis with infection, etc., characterized by coughing, vomiting, fishy odor, purulent sputum. Often used together with reed roots, peach kernels, and winter melon kernels, such as reed stem soup.

Intestinal abscess: equivalent to acute appendicitis, often used in combination with aconite and abscisic acid, such as Coix seed aconite abscisic acid powder.

3. Relieve rheumatism, relax muscles and relieve pain
Coix seed can penetrate dampness, relieve rheumatism, promote joint function, and alleviate muscle spasms.

Main applications:
Damp heat arthralgia: Especially suitable for rheumatic fever arthralgia, characterized by joint redness, swelling, heat pain, and poor flexion and extension (similar to acute rheumatoid arthritis and gouty arthritis). Often combined with self-defense, talc, gardenia, and other ingredients.

Damp rheumatism and spasms: Joint soreness, heaviness, muscle numbness, and muscle spasms caused by excessive dampness. It can be used alone or in combination with Atractylodes macrocephala, Qianghuo, and other herbs.

4. Detoxification and dispersal
This effect is increasingly valued in modern applications.

Main applications:
Warts and flat warts: Coix seed has antiviral and softening effects, and is often taken orally or topically to treat skin growths caused by HPV virus.

Tumor adjuvant therapy: Modern pharmacological research has shown that Coix seed (especially the extract “Kanglaite”) has certain anti-tumor effects and is often used as an adjuvant in traditional Chinese medicine tumor treatment, for strengthening the spleen and supporting the body, dispelling evil and dispersing nodules, and reducing the side effects of radiotherapy and chemotherapy.

Modern Pharmacological Effects of Semen Coicis (Yi Yi Ren)
1. Antitumor effect
This is currently one of the most concerned pharmacological activities of Coix seed.

Active ingredients: mainly coix seed ester and coix seed oil.

Mechanism of action:
Direct inhibition of tumor cells: can induce apoptosis (programmed cell death) of tumor cells and inhibit tumor cell proliferation.

Blocking tumor angiogenesis: The growth and metastasis of tumors require new blood vessels to provide nutrition. Coix seed can inhibit the growth of vascular endothelial cells, thereby “starving” tumors.

Regulating immune function: enhancing the activity of immune cells such as natural killer cells and macrophages, and using the body’s own immune system to attack tumor cells.

Reversing multidrug resistance: Combined with certain chemotherapy drugs, it can increase the sensitivity of tumor cells to chemotherapy drugs.

Application: Its injection (such as Kanglaite injection) has been widely used in clinical practice for adjuvant therapy of various tumors such as lung cancer, liver cancer, and gastric cancer. It can improve patients’ symptoms, enhance their quality of life, and reduce the toxic side effects of radiotherapy and chemotherapy.

2. Immune regulatory effect
Coix seed has a “bidirectional regulatory” effect on the immune system.

Active ingredient: Coix seed polysaccharide is the main active ingredient.

Mechanism of action:
Can promote the proliferation and differentiation of lymphocytes and macrophages, and enhance their phagocytic ability.

Stimulate the production of cytokines such as interferon, interleukin, etc., thereby enhancing the body’s non-specific and specific immunity (including cellular and humoral immunity).

Application: This is also the immunological basis for its ability to “strengthen the body” (enhance physical fitness) and assist in anti-tumor treatment.

3. Hypoglycemic and lipid-lowering effects
Active ingredients: Coix seed polysaccharides, dietary fiber, etc.

Mechanism of action:
Hypoglycemia: Increases insulin sensitivity, protects pancreatic beta cells, inhibits gluconeogenesis (the process by which the liver produces glucose), and delays intestinal absorption of carbohydrates.

Regulating blood lipids: reducing serum total cholesterol, triglycerides, and low-density lipoprotein (“bad” cholesterol) levels, while possibly increasing high-density lipoprotein (“good” cholesterol) levels.

Application: It has positive significance for the dietary adjuvant treatment of type 2 diabetes and hyperlipidemia.

4. Anti inflammatory and analgesic effects
This provides a scientific basis for the treatment of arthritis with traditional Chinese medicine’s methods of “removing rheumatism, relaxing tendons, and relieving pain”.

Active ingredients: Coix seed extract, Coix seed oil, and various ester components.

Mechanism of action: It can significantly inhibit the production and release of various inflammatory factors (such as prostaglandins, leukotrienes, tumor necrosis factor – α, etc.), thereby reducing inflammation and pain.

Application: It has a relieving effect on inflammatory pain such as rheumatoid arthritis and gouty arthritis.

5. Protecting the kidneys and promoting diuresis
This confirms its traditional efficacy of “promoting water circulation and moistening”.

Mechanism of action:
Diuretic: It can inhibit the reabsorption of sodium and chloride ions by the renal tubules, thereby producing a diuretic effect and helping to eliminate excess water from the body.

Kidney protection: It can protect glomerulus and tubular cells, reduce renal fibrosis, and delay the progress of chronic kidney diseases such as diabetes nephropathy.

6. Regulating intestinal function
This corresponds to its effect of “strengthening the spleen and stopping diarrhea”.

Mechanism of action:
Coix seed is rich in dietary fiber and can regulate the balance of gut microbiota.

It has a bidirectional regulatory effect on intestinal smooth muscle – it can both counteract intestinal spasms caused by acetylcholine (relieve diarrhea) and promote normal intestinal peristalsis (prevent constipation).

7. Other functions
Antiviral: Research has found that Coix seed extract has inhibitory effects on human papillomavirus, which causes flat warts and common warts, providing a basis for its “detoxification and dispersing” treatment of warts. In addition, it also has certain inhibitory activity against influenza virus, herpes simplex virus, etc.

Antioxidant: Phenolic and flavonoid compounds in Job’s tears have the ability to scavenge free radicals, which helps to delay aging and prevent chronic diseases.

Improving osteoporosis: Some studies have shown that Coix seed extract can promote osteoblast generation, inhibit osteoclast activity, and help maintain bone health.