Lindera Aggregata (Wu Yao) Extract Powder 10:1, 20:1, 50:1 TLC
【Other names】: Wu Yao, Radix Linderae, Combined Spicebush Root, Tian Tai Wu Yao
【Botanical source】: Lindera aggregata（Sims）Kos-term
【Part used】: This product is the dried root of Lindera aggregata (Sims) Kos term, a plant of the Lauraceae family. Excavate all year round, remove fine roots, wash, slice fresh, sun dry, or directly sun dry.
【Specification】: 10:1, 20:1, 50:1 TLC
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size

Lindera Aggregata (Wu Yao) Extract Powder Production Flowchart
Lindera Aggregata (Wu Yao) raw materials – natural air drying–Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification Sheet of Lindera Aggregata (Wu Yao) Extract Powder

Extended Reading
Lindera Aggregata (Wu Yao) Function and Efficacy Recorded in TCM
Wu Yao is a very important qi regulating medicine in traditional Chinese medicine, especially known for warming and dispelling cold, promoting qi circulation and relieving pain. Its medicinal properties are mild, and its main sites of action are in the middle and lower energizer (spleen and stomach, liver and kidney).

Below is a detailed analysis of the role of Wu medicine in traditional Chinese medicine.

Black medicine has a pungent taste and a warm nature. Return to the spleen, lungs, kidneys, and bladder meridians. Its core function is to promote qi circulation and relieve pain, warm the kidneys and dispel coldness. The characteristic is to “regulate the upper and lower qi”, which can clear the cold and stagnant qi from the chest and abdomen to the bladder.

1. Relieve pain through Qi circulation and relieve swelling with a wide and moderate range
Wu Yao Xin San Wen Tong is good at clearing qi and treating pain and bloating caused by qi stagnation and cold coagulation.

Location of action: Mainly acts on the spleen and stomach (middle energizer) and liver meridian.

Indications:
Chest and abdominal distension and pain caused by cold stagnation and qi stagnation: manifested as cold pain and fullness in the stomach, abdomen, or chest and abdomen, which is relieved when warm.

Cold hernia and abdominal pain: refers to the acute pain in the lower abdomen caused by cold pathogenic factors, which can be pulled to the testicles.

Dysmenorrhea: Black medicine has a good effect on the cold and bloating pain in the lower abdomen during menstruation caused by uterine coldness, qi stagnation, and blood stasis.

2. Warm the kidneys and dispel coldness, reduce urine and stop sequelae
Wu Yao enters the kidney and bladder meridians, can warm and disperse the cold air in the kidney and bladder, and consolidate the lower energy.

Location of action: Mainly acts on the kidneys and bladder (inferior focus).

Indications:
Frequent urination and enuresis due to bladder deficiency and coldness: manifested as frequent urination, especially nocturia, or enuresis in children. This is a very unique and commonly used efficacy of black medicine.

Kidney Yang Deficiency Cold: Often used together with other kidney warming drugs to treat symptoms such as cold and painful waist and knees.

Modern Pharmacological Effects of Lindera Aggregata (Wu Yao)
The modern pharmacological research on traditional Chinese medicine has been quite in-depth, and these studies have scientifically verified and enriched the understanding of its traditional efficacy in traditional Chinese medicine. The pharmacological activity of Wuyao mainly comes from its volatile components (such as Wuyao ether lactone, Wuyao alcohol), alkaloids, furan sesquiterpenes and their lactones, etc.

The following are the main modern pharmacological effects of black medicine:
1. Regulating effect on the digestive system
This is a direct confirmation of its efficacy in promoting qi circulation, relieving pain, and relieving swelling.

Bi directional regulation of gastrointestinal motility:
Spasmodic effect: The volatile oil components in black medicine can effectively inhibit excessive spasms of smooth muscles in the gastrointestinal tract, thereby relieving abdominal pain caused by qi stagnation and cold coagulation.

Excitatory effect: On the other hand, its extract can promote intestinal peristalsis, accelerate the expulsion of gas from the intestine, and alleviate bloating. This bidirectional regulatory effect enables it to effectively respond to various complex gastrointestinal functional disorders.

Anti gastric ulcer: Extracts of Wuyao have the effects of anti gastric acid and protecting gastric mucosa, which helps prevent and treat experimental gastric ulcers.

Hepatoprotective and choleretic effects: Studies have shown that black medicine has the ability to protect liver cells and promote bile secretion.

2. Anti inflammatory and analgesic effects
This is the core pharmacological basis for its analgesic effect.

Analgesia: The water and alcohol extracts of Wuyao have shown clear analgesic effects in various experimental models, such as the hot plate method and torsion method.

Anti inflammatory: Wu Yao can significantly inhibit the production and release of various inflammatory factors, reduce capillary permeability and tissue edema, thereby combating acute and chronic inflammation. This is closely related to the treatment of inflammatory pain such as hernia and dysmenorrhea.

3. Antibacterial and antiviral effects
Antibacterial: The volatile oil components of black medicine have varying degrees of inhibitory effects on various Gram positive and Gram negative bacteria (such as Staphylococcus aureus, Escherichia coli, Shigella, etc.).

Antiviral: Some studies have found that extracts of black medicine have antiviral activity against respiratory syncytial virus and other viruses.

4. Effects on the cardiovascular system
Exciting the myocardium and accelerating blood circulation: Wu Yao can enhance myocardial contractility and accelerate blood circulation, providing a scientific explanation for its “warming and dispersing cold” effect. By improving local blood circulation, it helps to dispel cold pathogens and qi stagnation.

Anticoagulation and Hemostasis: Studies have found that black medicine has anti platelet aggregation effects and can prevent thrombosis. At the same time, some of its components also have the effect of promoting coagulation, reflecting complex multi-component regulatory effects.

5. Antitumor effect
Preliminary research: A number of in vitro and animal experiments have shown that the active ingredients in the herbal medicine (such as myrrholides, some sesquiterpenes) have the effects of inhibiting proliferation, inducing apoptosis and inhibiting metastasis on a variety of cancer cells (such as liver cancer, breast cancer, lung cancer, etc.).

Mechanism: It may exert its effect through mechanisms such as affecting the cell cycle, activating apoptotic signaling pathways, and inhibiting tumor angiogenesis.

Current situation: It is still in the experimental research stage and is a potential direction for future drug development.

6. Antioxidant effect
The flavonoids and other components in black medicine have the ability to scavenge free radicals, which can alleviate the damage of oxidative stress to body tissues. This is related to their anti-aging, anti-inflammatory, and organ protective effects.

7. Effects on the nervous system
Muscle relaxation: The components of black medicine have a certain central muscle relaxation effect.

Neuroprotection: Some studies suggest that it may have protective potential for the nervous system.