Polygala(Yuan Zhi) Extract Powder 10:1, 20:1, 50:1 TLC
【Other names】: Yuan Zhi, Radix Polygalae, polygala root
【Botanical source】: Polygala tenuifolia Willd. , Polygala sibirica L.
【Part used】: Dry roots of Polygala tenuifolia Willd or Polygala sibirica L, a plant in the family Polygalaceae. Excavate in spring and autumn, remove roots and sediment, and dry or extract wood cores for drying.
【Specification】: 10:1, 20:1, 50:1 TLC
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size

Polygala(Yuan Zhi) Extract Powder Production Flowchart
Polygala(Yuan Zhi) raw materials – natural air drying–Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing
Specification Sheet of Polygala(Yuan Zhi) Extract Powder

Extended Reading
Polygala(Yuan Zhi) Function and Efficacy Recorded in TCM
Yuanzhi, a traditional Chinese medicine, is a very core calming and cognitive medicine in traditional Chinese medicine. It has the effects of calming the mind, enhancing intelligence, connecting the heart and kidneys, eliminating phlegm, and reducing swelling. Treatment for insomnia, frequent dreaming, forgetfulness, palpitations, confusion, unsatisfactory sputum production, swollen and toxic sores, and breast swelling and pain caused by heart kidney failure.

Core medicinal properties and meridian tropism

Medicinal properties: pungent, bitter, slightly warm.

Channel tropism: Heart, kidney, and lung meridians.

Core efficacy: calming the heart and mind, dispelling phlegm and opening the orifices, and dissipating abscesses and swelling.

Yuanzhi mainly acts on the heart and kidneys, calming the mind and enhancing intelligence through communication between the heart and kidneys; At the same time, its pungent and bitter properties can act on the lungs to reduce phlegm and dispel the body’s swelling.

Detailed efficacy and clinical application

1. Soothing and puzzle solving (core efficacy)
This is the most well-known function of Yuanzhi. Traditional Chinese Medicine believes that ‘the heart contains the spirit’, which is responsible for the person’s mental, conscious, and thinking activities. The kidney stores essence, essence generates marrow, and marrow converges in the brain, which is closely related to human memory.

Mechanism of action: Yuanzhi enters the heart and kidney meridians, and can communicate with the heart and kidneys. When the kidney yin is insufficient and cannot provide relief to the heart, leading to excessive heart fire and disturbance of the mind, symptoms such as insomnia, frequent dreams, and forgetfulness may occur. Yuanzhi can bring kidney qi up to the heart and heart fire down to the kidneys, thereby restoring mental peace and improving intelligence.

Indications:
Insomnia, frequent dreams, palpitations: Whether it is restlessness caused by heart kidney dysfunction or heart qi deficiency, it can be used. Often used together with tranquilizers such as Fu Shen, Dragon Teeth, cinnabar, etc.

Forgetfulness and lack of concentration: Due to their ability to improve intelligence, they are essential medicines for treating forgetfulness. In the famous book health prescription “Kong Sheng Zhen Zhong Dan”, there is Yuanzhi, which is used together with Acorus tatarinowii, turtle shell, and dragon bone to enhance memory and learning ability.

2. Dispelling phlegm and opening up orifices

Yuanzhi can benefit the mind and expel phlegm and saliva.

Expelling phlegm: particularly adept at transforming phlegm from the heart and mind. When phlegm clouds the mind, it can lead to abnormal consciousness, such as epileptic seizures, palpitations, and dizziness. Yuanzhi can expel phlegm and open the orifice, making the mind clear.

Kaiqiao: Used to treat drowsiness, confusion, and delayed response caused by phlegm dampness obstructing the clear orifice (brain).

Coughing: It also enters the lung meridian, promotes bronchial secretion, dilutes phlegm, and thus plays a role in dispelling phlegm and stopping cough. It is used to treat thick and sticky phlegm, cough and vomiting discomfort.

3. Dissolve abscess and swelling

Mechanism of action: With its properties of promoting circulation and warming, it can clear the stagnation of qi and blood and reduce swelling.

Indications:
Ulcers and toxins, breast swelling and pain: Especially at the beginning, Yuanzhi powder can be used, and alcohol can be taken or applied to the affected area, which has a good effect on reducing swelling and relieving pain. Modern adjuvant therapy is also commonly used for acute mastitis.

Modern Pharmacological Effects of Polygala

The pharmacological activity of Yuanzhi is mainly attributed to the following three categories of ingredients:

Saponins: Polygala saponins are its main active ingredients, including Polygala saponins A, B, C, D, etc., which have significant effects on the central nervous system and respiratory system.
Oligosaccharides esters: such as those from Polygala tenuifolia and Scutellaria baicalensis, have neuroprotective and cognitive improving effects.
And alkaloids, flavonoids, etc.

1. Effects on the central nervous system

Improving Learning and Memory and Preventing Dementia:
This is a modern manifestation of the “intelligence enhancing” effect of Yuanzhi. Yuanzhi saponins and oligosaccharide esters can promote the synthesis and expression of nerve growth factors, protect cholinergic neurons, increase acetylcholine content in the brain, and significantly improve learning and memory abilities.

It has shown great potential in combating Alzheimer’s disease, reducing the deposition of β – amyloid protein and inhibiting excessive phosphorylation of Tau protein, making it a hot topic in current research on traditional Chinese medicine for anti dementia.

Sedation, anti anxiety, and anti depression:
Yuanzhi extract can significantly prolong sleep time and reduce spontaneous activity, confirming its “calming” effect.

Its anti anxiety and anti depression effects are related to regulating the levels of monoamine neurotransmitters (such as serotonin, dopamine, norepinephrine), protecting hippocampal neurons, and regulating the function of the hypothalamic pituitary adrenal axis.

Neuroprotection and anti-aging:
Has strong antioxidant activity, can clear free radicals, and alleviate oxidative stress damage to brain tissue.

It can promote the proliferation and differentiation of nerve cells, and has potential therapeutic value for neurodegenerative diseases such as cerebral ischemia and Parkinson’s disease.

2. expectorant and cough suppressant effects
Mechanism: Yuanzhi saponins have a stimulating effect on the gastric mucosa, reflexively promoting increased secretion of bronchial mucosa, diluting sputum, and making it easier to cough up.

Application: This provides a precise scientific basis for its traditional use in treating cough and phlegm.

3. Anti inflammatory and antioxidant effects
Anti inflammatory: Yuanzhi extract has inhibitory effects on various acute and chronic inflammation models, and can inhibit the production of inflammatory factors such as TNF – α and IL-6.

Antioxidant: Its flavonoids and saponins are effective antioxidants, which are not only related to its neuroprotective effects, but also provide support for the traditional saying of “longevity”.

4. Antitumor effect
Studies have shown that polygala saponins and polygala polysaccharide can inhibit proliferation and induce apoptosis of various cancer cells (such as lung cancer, liver cancer, breast cancer) in vitro and in animal experiments.

Mechanism of action: may involve cell cycle arrest, activation of apoptotic signaling pathways, inhibition of tumor angiogenesis, etc. Attention: This is currently mainly in the preclinical research stage.

5. Other function
Cardiovascular protection: It has the effects of lowering blood pressure, lowering blood lipids, and inhibiting platelet aggregation.
Enhancing immunity: Polysaccharides from Yuanzhi can enhance non-specific immune function in the body.