Rehmannia (Sheng Di Huang) Extract Powder 10:1, 20:1, 50:1 TLC
【Other names】: Di Huang, Sheng Di Huang, Sheng Di, Radix Rehmanniae, Rehmannia Root, Gan Di Huang
【Botanical source】: Rehmannia glutinosa Libosch.
【Part used】: Fresh or dried tubers of Rehmannia glutinosa Libosch, a plant in the family Scrophulariaceae. Excavate in autumn, remove reed heads, fibrous roots, and sediment, and use fresh; Or slowly bake Rehmannia glutinosa until it is about 80% dry.
【Specification】: 10:1, 20:1, 50:1 TLC
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size

Rehmannia (Sheng Di Huang) Extract Powder Production Flowchart
Rehmannia (Sheng Di Huang) raw materials – natural air drying–Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing
Specification Sheet of Rehmannia (Sheng Di Huang) Extract Powder

Extended Reading
Rehmannia (Sheng Di Huang) Function and Efficacy Recorded in TCM
Shengdi, also known as Shengdi, is the dried root tuber of the Scrophulariaceae plant, Rehmannia glutinosa. It is made by baking fresh Rehmannia glutinosa to 80% of its original value. Its medicinal properties are in line with those of fresh Rehmannia glutinosa, but it focuses more on “nourishing yin” and is the core medicine in traditional Chinese medicine for clearing heat, cooling blood, nourishing yin and generating fluids. Its nature is sweet, bitter, cold, and it belongs to the heart, liver, and kidney meridians.

1. Clear heat and cool blood
This is one of the most important functions of Rehmannia glutinosa, which is good at clearing the pathogenic heat that penetrates deep into the blood.

Mechanism of action: Sexual coldness enters the bloodstream, which can eliminate heat toxins in the bloodstream, prevent heat pathogens from burning the blood vessels, and cool down the heat of yin blood.

Indicative symptoms:
Warm illness and heat entering the bloodstream: manifested as intense body heat at night, restlessness and insomnia, deep red tongue (purple tongue), and even confusion and talking nonsense. Often combined with ingredients such as Xuanshen, honeysuckle, Huanglian, etc., such as the famous formula “Qingying Tang”.

Blood heat bleeding: Vomiting, nosebleeds (nosebleeds), hematuria, rectal bleeding, skin spots, etc. caused by excessive blood heat. Often combined with side cypress leaves, mugwort leaves, etc., such as “Four Lives Pill”.

Internal heat and thirst quenching: diabetes (thirst quenching disease) caused by internal heat due to yin deficiency, manifested as polydipsia, polydipsia, polyuria, and often compatible with radix trichosanthin, radix puerariae, radix astragali, etc.

2. Nourish Yin and generate fluids
This is another major core function of Rehmannia glutinosa, which has a moisturizing texture and can nourish the body’s yin fluid.

Mechanism of action: Sweet in taste, cold in nature, moist in texture, able to nourish yin fluids to control yang heat, and replenish body fluids that have been depleted.

Indicative symptoms:
Fever harms yin: In the later stage of febrile diseases, most of the pathogenic heat has subsided, but the body’s fluids have been consumed, resulting in dry mouth and tongue, sore throat, low-grade fever that does not subside, and red tongue with little coating. Often combined with sand ginseng, Ophiopogon japonicus, Yuzhu, etc., such as “Yiwei Tang”.

Yin deficiency and internal heat: Used for various chronic diseases caused by Yin deficiency and excessive fire, manifested as bone steaming and hot flashes (like heat seeping out of bones), night sweats, hand foot and heart heat, etc. Often used interchangeably with Zhimu and Di Gu Pi.

Jin Shang Constipation: Dry stool caused by deficiency of yin fluid and loss of intestinal lubrication. It is often combined with black ginseng and Ophiopogon japonicus to form the famous “Zengye Tang”, which uses the method of “increasing water and rowing” to relieve constipation.

Modern Pharmacological Effects of Rehmannia (Di Huang)
The main active ingredients of Rehmannia glutinosa include iridoid glycosides (such as catalpol and motherwort glycosides), sugars (such as raffinose and Rehmannia polysaccharides), amino acids, sterols, etc. The following are the main modern pharmacological effects of Rehmannia glutinosa:

1. Effects on the immune system
This is one of the most prominent and distinctive pharmacological effects of Rehmannia glutinosa, closely related to its efficacy in treating autoimmune diseases and regulating the body’s defense capabilities.

Inhibit abnormal immunity/anti-inflammatory:
Function: Rehmannia glutinosa can inhibit excessive immune and inflammatory reactions in the body.

Mechanism: It can inhibit the excessive activation and proliferation of T lymphocytes, regulate the production of cytokines (such as TNF – α, IL-1 β, IL-6), thereby reducing tissue inflammation and immune damage.

Related applications: This provides a scientific basis for the use of Rehmannia glutinosa in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and allergic purpura, reflecting some of the connotations of “clearing heat and cooling blood”.

Enhance low immunity:
Function: Rehmannia polysaccharides are the main immune enhancing components.

Mechanism: It can promote the phagocytic function of macrophages, stimulate the proliferation and differentiation of hematopoietic stem cells, and enhance the non-specific immune function of the body.

2. Effects on endocrine and metabolism
Hypoglycemic effect:
Raw Rehmannia glutinosa and its active ingredients (such as catalpol and Rehmannia glutinosa polysaccharide) have significant hypoglycemic effects on normal and various diabetes model animals.

Mechanism: may include protecting pancreatic beta cells, improving insulin resistance, promoting peripheral tissue utilization of glucose, inhibiting glycogen breakdown, etc.

Associated application: This directly confirms its traditional efficacy in treating “internal heat and thirst quenching” (i.e. diabetes).

Effects on the adrenal cortex axis:
Rehmannia glutinosa can alleviate the feedback inhibition of glucocorticoids (such as dexamethasone) on the body’s own adrenal cortex function, helping to protect adrenal cortex function. This is of great significance in the long-term use of hormone therapy.

3. Effects on the cardiovascular system
Strengthening the Heart and Lowering Blood Pressure:
Heart strengthening: Rehmannia glutinosa has a slight heart strengthening effect, especially on weakened hearts.

Hypotension: Its decoction, alcohol extract, etc. have antihypertensive effects on various animal models.

Mechanism: It may be related to promoting vasodilation, diuresis, and central sedative effects.

Improving heart function and anti myocardial ischemia:

Rehmannia glutinosa helps improve myocardial energy metabolism and has a protective effect on ischemic and hypoxic myocardial cells.

4. Promote hematopoiesis and hemostasis
Promoting hematopoiesis: Rehmannia glutinosa can stimulate the proliferation and differentiation of hematopoietic progenitor cells, accelerate the recovery of red blood cells and hemoglobin, and have a significant “blood replenishing” effect, which is consistent with its traditional theory of “nourishing yin and generating saliva” to transform and produce blood.

Hemostasis: Rehmannia glutinosa can shorten clotting time and help stop bleeding, providing a basis for its “cooling blood and stopping bleeding” effect.

5. Antitumor effect
Research has shown that extracts of Rehmannia glutinosa and Rehmannia polysaccharides have inhibitory effects on proliferation and induce apoptosis in certain cancer cell lines, such as lung cancer, gastric cancer, and liver cancer. Its mechanism may be related to regulating the body’s immune function, directly inhibiting tumor cells, and anti-tumor angiogenesis.

6. Neuroprotection and anti-aging
Neuroprotection: The main active ingredient, catalpol, has been proven to have significant neuroprotective effects. It can improve learning and memory abilities and has a positive impact on animal models of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The mechanism may be related to antioxidant activity, inhibition of neuronal apoptosis, and promotion of nerve growth factor expression.

Antioxidant: Rehmannia glutinosa can eliminate free radicals and reduce the damage of oxidative stress to body tissues, which is related to anti-aging and delaying the development of various chronic diseases.

7. Anti inflammatory and sedative effects
Anti inflammatory: It has inhibitory effects on various experimental inflammation models.

Sedation: Rehmannia glutinosa has a central sedative effect, which helps to improve symptoms such as restlessness and insomnia. This corresponds to the effect of “clearing heat and cooling blood” to calm the mind.