Ziziphus Jujuba(Suan Zao Ren) Extract Powder 10:1, 20:1, 50:1 TLC
【Other names】: Suan Zao Ren, Semen Ziziphi Spinosae, Spina Date Seed, Zao Ren, Ziziphi Spinosae Semen, Sour Jujube Kernels
【Botanical source】: Ziziphus jujuba Mill. var. spinosa（Bunge）Hu ex H. F. Chou
【Part used】: Dried and mature seeds of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou, a plant in the Rhamnaceae family. Harvest mature fruits in late autumn and early winter, remove the flesh and core-shell, collect seeds, and dry them in the sun.
【Specification】: 10:1, 20:1, 50:1 TLC
【Appearance】: Brownish yellow fine powder
【Particle size】: 95% pass 80 mesh size

Ziziphus Jujuba(Suan Zao Ren) Extract Powder Production Flowchart
Ziziphus Jujuba(Suan Zao Ren) raw materials – natural air drying–Coarse powder(40 mesh) -Low temperature water extraction – 1^st Reflux Extraction(10 times water,2 Hrs) – 2^nd Reflux Extraction8 times water,1.5 Hrs) – 3rd Reflux Extraction(6 times water,1 Hrs) – Extraction Solution-combine&Filtrate-Concentrate-Extractum-spray drying – screening – packaging – detection of physical and chemical indicators – warehousing
Specification Sheet of Ziziphus Jujuba(Suan Zao Ren) Extract Powder

Extended Reading
Ziziphus Jujuba(Suan Zao Ren) Function and Efficacy Recorded in TCM
Ziziphus Jujuba(Suan Zao Ren) is a very classic and important calming medicine in traditional Chinese medicine, known as the “sleeping fruit of the East”. Its core function is to “nourish the heart yin, benefit the liver blood” and calm the mind. Sour jujube kernels have sweet, sour, and flat medicinal properties; The core function of sour jujube kernels is to nourish the heart, liver, and gallbladder, calm the mind, and reduce sweating. In general, sour jujube kernels are a nourishing medicine that acts on the heart and liver. They have a peaceful nature and mainly achieve a calming effect by nourishing Yin blood.

1. Nourish the heart and calm the mind
This is the most fundamental and well-known function of jujube kernels. It is mainly used for the loss of mind and spirit caused by liver and liver blood deficiency.

Pathogenesis: Heart controls blood, liver stores blood. Blood deficiency leads to a loss of nourishment for the heart, causing liver and soul anxiety, and ultimately resulting in restlessness.

Typical symptoms: Insomnia and frequent dreaming: Especially when feeling restless and unable to sleep, feeling restless but physically exhausted.

Palpitations and palpitations: feeling a restless heartbeat and palpitations.

Application: This is the absolute therapeutic field of sour jujube kernels. The famous Anshen Ancestral Formula “Suanzaoren Tang” (derived from “Jin Kui Yao Lue”) is mainly used as this medicine, specifically for the treatment of “deficiency, fatigue, restlessness, and insomnia”.

2.Nourishing Yin and Suppressing Sweat
Sour jujube kernels have a sour taste and can be astringent, so they also have the effect of stopping sweating.

Pathogenesis: Used for Yin deficiency and night sweats. At night, it belongs to Yin, and Yin deficiency cannot control Yang. Yang qi spreads outward, forcing body fluids to go out, resulting in sweating after falling asleep and stopping sweating after waking up.

Typical symptoms: Sweating after falling asleep at night and stopping sweating after waking up.

Application: Often used together with nourishing yin and reducing sweating medicines such as Schisandra chinensis, Cornus officinalis, oysters, etc.

3.Nourish the liver and gallbladder
Sour jujube kernels can enter the liver and gallbladder meridians, and have therapeutic effects on weak and easily frightened gallbladder qi.

Pathogenesis: Insufficient liver blood and weak gallbladder qi.

Typical symptoms: In addition to insomnia, it is also accompanied by startle, timidity, and fear.

Application: Often used in combination with Chuanxiong, Zhimu, Fuling, etc., and processed on the basis of Suanzaoren Tang.

Modern Pharmacological Effects of Sour Jujube Kernels
1. Effects on the central nervous system

Sedative and hypnotic effects:
Mechanism: Jujube seed saponins and flavonoids (such as spinosin) can enhance the function of the inhibitory neurotransmitter GABA (gamma aminobutyric acid) in the brain, while reducing the level of excitatory neurotransmitters, thereby inhibiting excessive excitation of the central nervous system.

Characteristics: It is not a mandatory sedative, but a synergistic one that can significantly prolong slow wave sleep (deep sleep) time and improve sleep quality, which is highly consistent with the traditional view that it “nourishes the heart and mind” rather than “strongly calms down”.

Anti anxiety effect:
Its extract can effectively alleviate anxiety behavior in experimental animals, and its mechanism of action is related to the regulation of the 5-hydroxytryptamine (5-HT) system and the hypothalamic pituitary adrenal axis (HPA axis).

Improving Learning Memory and Neuroprotection:
Suanzaoren can improve learning and memory disorders caused by various reasons and has a protective effect on Alzheimer’s disease models.

Mechanisms: including antioxidant activity, reduction of beta amyloid toxicity, protection of cholinergic neurons, inhibition of neuronal apoptosis, etc.

Antidepressant effect:
Research has shown that it has potential antidepressant activity, which may be related to increasing levels of monoamine neurotransmitters such as norepinephrine and serotonin in the brain.

3. Effects on the cardiovascular system
Antiarrhythmic effects: Extracts from jujube seeds have significant preventive and therapeutic effects on various experimental arrhythmias, slowing down heart rate and combating arrhythmias caused by adrenaline and other factors.

Protecting myocardium and improving ischemia: It can dilate coronary arteries, increase coronary blood flow, enhance myocardial hypoxia tolerance, and have a protective effect on ischemic myocardium.

Lowering blood pressure: By directly acting on the vascular wall and central regulation, it produces a mild and long-lasting hypotensive effect.

4. Antioxidant and anti-inflammatory effects
Antioxidant: Flavonoids and saponins in jujube seeds are powerful antioxidants that can effectively eliminate free radicals and reduce oxidative stress damage, which is closely related to their anti-aging and neuroprotective effects.

Anti inflammatory: It can inhibit the production of various inflammatory factors, such as tumor necrosis factor – α (TNF – α), interleukin-6 (IL-6), etc., thereby exerting anti-inflammatory effects.

5. Other functions
Enhancing immunity: Jujube seed polysaccharides can enhance the body’s non-specific and specific immunity (including cellular and humoral immunity) functions.

Hypolipidemic: It has the effect of reducing blood lipid and anti atherosclerosis on experimental hyperlipidemic animals.